Tissue Doppler imaging consistently detects myocardial contraction and relaxation abnormalities, irrespective of cardiac hypertrophy, in a transgenic rabbit model of human hypertrophic cardiomyopathy.

نویسندگان

  • S F Nagueh
  • H A Kopelen
  • D S Lim
  • W A Zoghbi
  • M A Quiñones
  • R Roberts
  • A J Marian
چکیده

BACKGROUND Hypertrophic cardiomyopathy (HCM) is diagnosed clinically by the presence of left ventricular hypertrophy (LVH). However, LVH is absent in a significant number of genotype-positive patients. Because myocyte dysfunction and disarray are the primary abnormalities in HCM, we reasoned that tissue Doppler imaging could identify contraction and relaxation abnormalities, irrespective of hypertrophy, in a transgenic rabbit model of human HCM. METHODS AND RESULTS M-mode, 2D, Doppler echocardiography and tissue Doppler imaging were performed in nontransgenic (n=24), wild-type beta-myosin heavy chain-arginine(403) (n=14), and mutant beta-myosin heavy chain-glutamic acid(403) (n=24) transgenic rabbits. Mean septal thicknesses were 2.0+/-0.3, 2.0+/-0.25, and 2.75+/-0.3 mm in the 3 groups, respectively (P:=0.001). LVH was absent in 9 of the 24 mutant rabbits. Left ventricular dimensions, systolic function, heart rate, mitral inflow velocities, and time intervals were similar in the groups. However, the difference between atrial reversal and transmitral A wave duration was increased in the mutant rabbits (P:<0.001). More importantly, systolic and early diastolic tissue Doppler velocities were significantly lower in all mutant rabbits (7.45+/-2.2 versus 10.8+/-2.3 cm/s in nontransgenic and 9. 0+/-0.76 cm/s in wild-type; P:<0.001), including the 9 without LVH. A systolic velocity <8.5 cm/s had an 86% sensitivity and 100% specificity in identifying the mutant transgenic rabbits. CONCLUSIONS Myocardial contraction and relaxation were reduced in the mutant beta-myosin heavy chain-glutamic acid(403) transgenic rabbit model of human HCM, irrespective of the presence or absence of LVH. In addition, tissue Doppler imaging is more sensitive than conventional echocardiography for HCM screening.

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منابع مشابه

Human Hypertrophic Cardiomyopathy Abnormalities, Irrespective of Cardiac Hypertrophy, in a Transgenic Rabbit Model of Tissue Doppler Imaging Consistently Detects Myocardial Contraction and Relaxation

Sherif F. Nagueh, Helen A. Kopelen, Do-Sun Lim, William A. Zoghbi, Miguel A. Quiñones, Human Hypertrophic Cardiomyopathy Abnormalities, Irrespective of Cardiac Hypertrophy, in a Transgenic Rabbit Model of Tissue Doppler Imaging Consistently Detects Myocardial Contraction and Relaxation Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2000 American Heart Association, Inc. All rights res...

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عنوان ژورنال:
  • Circulation

دوره 102 12  شماره 

صفحات  -

تاریخ انتشار 2000